Tumor cells steal methionine from CD8 T cells. High expression of the methionine transporters SLC7A5 and SLC43A2 allows tumor cells to outcompete CD8 T cells for methionine uptake. Lower methionine concentrations in CD8 T cells lead to reduced levels of dimethylated H3K79, an active epigenetic mark, which in turn results in reduced STAT5 expression and activity
Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from oxidative p...
BackgroundThe majority of cancer cells have a unique metabolic requirement for methionine that is no...
Methionine dependence is a metabolic defect characterized by the inability of eukaryotic cells in cu...
Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours1–4, but the cause...
The majority of cancer cells have a unique metabolic addiction to methionine in contrast to normal c...
Understanding cellular metabolism holds immense potential for developing new classes of therapeutics...
Objective. The effects of methionine gamma lyase-deaminase (Mgld) on cancer cells. Background. Methi...
Methionine is an essential amino acid used, beyond protein synthesis, for polyamine formation and DN...
Methionine and homocysteine are metabolites in the transmethylation pathway leading to synthesis of ...
Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman Effect, is ...
Epigenetic modifications on DNA and histones activate or repress gene transcription by modulating ch...
The aim of this project was to investigate the importance of methionine depletion as a cause of cyto...
Targeting altered tumor cell metabolism might provide an attractive opportunity for patients with ac...
Methionine metabolism provides two key cellular reagents: S-adenosylmethionine and glutathione, deri...
Availability of the amino acid methionine shows remarkable effects on the physiology of individual c...
Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from oxidative p...
BackgroundThe majority of cancer cells have a unique metabolic requirement for methionine that is no...
Methionine dependence is a metabolic defect characterized by the inability of eukaryotic cells in cu...
Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours1–4, but the cause...
The majority of cancer cells have a unique metabolic addiction to methionine in contrast to normal c...
Understanding cellular metabolism holds immense potential for developing new classes of therapeutics...
Objective. The effects of methionine gamma lyase-deaminase (Mgld) on cancer cells. Background. Methi...
Methionine is an essential amino acid used, beyond protein synthesis, for polyamine formation and DN...
Methionine and homocysteine are metabolites in the transmethylation pathway leading to synthesis of ...
Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman Effect, is ...
Epigenetic modifications on DNA and histones activate or repress gene transcription by modulating ch...
The aim of this project was to investigate the importance of methionine depletion as a cause of cyto...
Targeting altered tumor cell metabolism might provide an attractive opportunity for patients with ac...
Methionine metabolism provides two key cellular reagents: S-adenosylmethionine and glutathione, deri...
Availability of the amino acid methionine shows remarkable effects on the physiology of individual c...
Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from oxidative p...
BackgroundThe majority of cancer cells have a unique metabolic requirement for methionine that is no...
Methionine dependence is a metabolic defect characterized by the inability of eukaryotic cells in cu...
DOI
Add to ORKG